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What other drugs will affect misoprostol?

What other drugs will affect misoprostol, Other drugs may interact with misoprostol, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your healthcare providers about all the medicines you use now and any medicines you started or stop using.

What is misoprostol?

Misoprostol reduces stomach acid and helps protect the stomach from damage that can be caused by taking a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.

Misoprostol is used to prevent stomach ulcers during treatment with aspirin or an NSAID.

What should I avoid while taking misoprostol?

Ask your doctor before using an antacid, and use only the type your doctor recommends. Some antacids can increase your risk of diarrhea while you are taking misoprostol.

Misoprostol side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe ongoing stomach discomfort or diarrhea; or
  • Dehydration symptoms–feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin.

Common side effects may include:

  • diarrhea;
  • stomach pain, nausea, upset stomach, gas;
  • vaginal bleeding or spotting, heavy menstrual flow; or
  • menstrual cramps.

How should I take misoprostol?

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Do not share this medicine with another person.

Misoprostol is usually taken with meals and at bedtime. Follow your doctor’s instructions.

You may have nausea, stomach cramps, or diarrhea while taking this medicine, especially during the first few weeks after you start taking misoprostol. These symptoms usually last for about a week.

Call your doctor if you have severe nausea, stomach pain, or diarrhea lasting longer than 8 days.

Read all medication guides or patient instructions provided with this medicine each time you receive a new supply.

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